Buy Melanotan II – 10 mg / $79.99
Melanotan II (MT‑2) is a synthetic cyclic heptapeptide and an analogue of α‑melanocyte‑stimulating hormone (α‑MSH), a natural neuropeptide from the melanocortin family. First synthesized in the 1980s at the University of Arizona during research on UV‑independent pigmentation, Melanotan II peptide is supplied as a high‑purity (≥98–99% by HPLC) lyophilized powder for laboratory research applications.
It functions as a non‑selective melanocortin receptor agonist and is widely studied in preclinical research involving pigmentation pathways, receptor pharmacology, and neuroendocrine signaling. Melanotan II is intended strictly for laboratory and animal research use only and is not approved for human consumption or therapeutic applications.
Melanotan II 10 mg
Melanotan II 10 mg refers to a research vial containing 10 mg of lyophilized synthetic peptide powder. This quantity supports multiple experimental procedures, including receptor binding studies, cell‑based assays, and animal model research.
The peptide is commonly supplied in acetate salt form with ≥98–99% purity. Vials are typically reconstituted using bacteriostatic or sterile water under sterile laboratory conditions to prepare working research solutions. The 10 mg format provides flexibility for both small‑scale in vitro experiments and extended in vivo investigations.
Melanotan II Mechanism of Action
In laboratory models, Melanotan II acts as a non‑selective agonist of melanocortin receptors, primarily MC1R, MC3R, MC4R, and MC5R. By mimicking α‑MSH, it binds to these G‑protein‑coupled receptors and activates intracellular signaling pathways, including increased cyclic AMP (cAMP) production associated with melanogenesis.
Key research observations include:
- Activation of MC1R receptors on melanocytes, promoting eumelanin production associated with darker pigmentation.
- Interaction with MC4R pathways linked to appetite regulation, energy balance, and neuroendocrine signaling.
- Additional activity at MC3R receptors involved in metabolic regulation.
This multi‑receptor activity makes MT‑2 useful for studying melanocortin system signaling and receptor dynamics in controlled research environments.
Melanotan II Peptide Sequence
Melanotan II is a cyclic heptapeptide with the following structure:
Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑NH₂
- Ac indicates N‑terminal acetylation for enhanced stability.
- Nle represents norleucine, a non‑natural amino acid substitution.
- A cyclic lactam bridge forms between Asp and Lys residues.
- Molecular formula: C₅₀H₆₉N₁₅O₉
- Molecular weight: ≈1024.2 Da
- CAS number: 121062‑08‑6
The cyclic structure improves resistance to enzymatic degradation, supporting experimental stability in research applications.
Recent Research Overview
Preclinical studies have investigated Melanotan II in animal models focusing on melanogenesis, pigmentation pathways, and photoprotection mechanisms. Research demonstrates increased melanin production and pigmentation responses even under minimal UV exposure.
Additional investigations explore melanocortin system involvement in metabolism, appetite regulation, and behavioral signaling pathways. Some animal studies also examine neuroendocrine responses associated with melanocortin receptor activation.
Despite limited exploratory human studies, Melanotan II remains an investigational compound. Current research primarily focuses on receptor signaling, pigmentation biology, and metabolic pathway modeling.
Storage and Handling
Melanotan II is supplied as a lyophilized powder for improved stability. Store unopened vials in a cool, dry, and dark environment. Long‑term storage is recommended at −20°C, although short‑term stability may be maintained at 2–8°C when protected from moisture and light.
After reconstitution with bacteriostatic or sterile water under sterile laboratory conditions, refrigerate solutions at 2–8°C and use within standard research timelines (typically 3–4 weeks). Avoid repeated freeze‑thaw cycles and exposure to contamination or direct light.
How Much Does Melanotan II 10 mg Cost?
The Melanotan II 10 mg research vial is priced at
$74.99. All peptides are manufactured in the USA, tested for high purity, and supplied strictly for laboratory research purposes.
Disclaimer
Melanotan II is an investigational research peptide intended solely for in vitro laboratory research and in vivo animal studies. It is not approved by the FDA, EMA, or any regulatory authority for human use, diagnosis, treatment, or supplementation.
This compound is classified as a non‑approved substance and may fall under restricted categories such as WADA S0. No claims are made regarding safety or effectiveness in humans. Products must be handled only in qualified laboratory environments with proper institutional oversight.
Referenced Citations
- Hadley ME, et al. Studies on melanotropic peptides and pigmentation research.
- Dorr RT, et al. Research on melanotropic peptides and UV‑related tanning mechanisms.
- Peptide Sciences and supplier analytical data regarding sequence and receptor activity (CAS 121062‑08‑6).
- Preclinical melanocortin receptor studies examining pigmentation and metabolic signaling.
