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TB-500 – 10 mg

10mg

TB-500, an effective and efficient synthetic peptide, is generally studied in a research environment to know about its natural functions, such as tissue repair, flexibility, and recovery.

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What is TB-500?

TB-500, an effective and efficient synthetic peptide, is generally studied in a research environment to know about its natural functions, such as tissue repair, flexibility, and recovery. It is derived from fragments of thymosin beta-4 (TB4), which itself is a naturally occurring protein of 43 amino acids and is found in almost every human cell. TB-500 works like the regenerative properties of TB4, targeting fast healing, as opposed to the complexity of the original protein. Readily available in the field of regenerative medicine, TB-500 is currently being studied for its potential use in aiding recovery from injuries, particularly those related to sports, and for its overall healing effects on tissues.

TB-500 Mechanism of Action

The mechanism of TB-500 is mainly based on interacting with actin, an important protein that works in cell motility and cell division. TB-500 specifically binds to globular actin or G-actin, which is important in cell migration, proliferation, and differentiation. Important mechanisms are:

1. Stimulation of Angiogenesis

TB-500 has the potential to promote the growth of new blood vessels, which bring oxygen and nourishment to tissues, particularly after injury.

2. Helping in Cell Migration

In a research setting, TB-500 has shown its effectiveness to help the cells, such as fibroblasts and keratinocytes, reach the site of injury for effective repair.

3. Dealing with inflammation

Moreover, in preclinical animal models it also has the potential to adjust the inflammatory response to prevent swelling, pain, and discomfort in clinical subjects.

4. Promotion of Tissue Regeneration

Also, TB-500 is studied for its potential effectiveness to accelerate tissue wound healing, collagen formation, muscle, tendon, and ligament repair, as well as the improvement of flexibility due to relaxation of muscle tissue. Though the research data show that TB-500 may be effective when dealing with inflammation and tissue regeneration, these studies are limited, and further research is needed to prove its effectiveness.

TB-500 Peptide Sequence

TB-500 is a synthetic heptapeptide or 7-amino acid chain, which is the active actin-binding domain of thymosin beta-4. N-terminally acetylated for stability and biological activity. Sequence of Amino acid: Ac-LKKTETQ (Ac represents N-terminal acetylation.)

TB-500 Research and Disclaimer

TB-500 research has shown very positive prospects for the new drug in terms of tissue repair, healing of wounds, and regeneration of tissue. In general, preclinical studies show accelerated healing across various modules. In preclinical animal studies, Thymosin Beta-4 and its synthetic derivative, i.e., TB-500, have shown an increase in the rate of dermal wound healing. For example, the topical or systematic administration in rats was observed to increase re- epithelization by 61% and has improved wound contraction, collagen deposition, and Angiogenesis. Reduced scarring and improved granulation tissue production have been reported. Other areas of current research include muscle, tendon, and ligament repair through faster recovery and decreased stiffness after injury. TB-500 within the research environment shows improved cardiac and vascular health through promoting blood vessel development and protecting the connective tissue. It is also observed to improve skin and hair regeneration by supporting the health of hair follicles and facilitating overall dermal healing. Recent studies are also beginning to investigate how TB-500 is metabolized, and several important metabolites (e.g., Ac-LK, Ac-LKKTE) have been identified. These metabolites appear to play a role in maintaining TB-500’s biological activity, and particularly, some metabolites (like Ac-LKKTE) have been shown to have potent wound healing activity in fibroblast-based models, indicating that some of the mechanisms of action may derive from these metabolites. Although there have been few human studies (with some phase II trials for thymosin beta-4 suggesting faster healing for venous stasis ulcers and pressure ulcers), there have been sufficient preclinical results affirming the Regenerative properties. Current studies are centered on detection, pharmacokinetics, and optimization for therapeutic purposes. TB-500 remains to be investigated for other applications in regenerative medicine, providing potential as well as promising results in injury repair and performance enhancement.

References

Esposito S, et al. (2012). Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500. Drug Testing and Analysis.
Malinda KM, et al. (1999). Thymosin beta4 accelerates wound healing. Journal of Investigative Dermatology (related to enhanced reepithelialization and angiogenesis).
Rahaman KA, et al. (2024). Simultaneous quantification of TB-500 and its metabolites… and their screening by wound healing activities in-vitro. Journal of Chromatography B.
WADA Scientific Research: Investigation of in vitro/ex vivo TB-500 metabolism, synthesis of relevant metabolites and detection limits.
Additional preclinical insights from studies on thymosin beta-4 in wound models including enhanced collagen organization and reduced scarring.

Research Use Only

This product is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Chemical Properties

Molecular Formula	C212H350N56O78S
Molecular Mass	4963 g/mol
Monoisotopic Mass	4960.4863169 Da
Polar Area	2250 Å²
Complexity	12200
XLogP	-43.5
Heavy Atom Count	347
Hydrogen Bond Donor Count	72
Hydrogen Bond Acceptor Count	88
Rotatable Bond Count	180
CID	16132341
InChI	InChI=1S/C212H350N56O78S/c1-16-106(7)166(261-190(323)131(64-75-160(292)293)231-172(305)109(10)228-174(307)134(78-91-347-15)245-196(329)140(98-165(302)303)255-201(334)147-53-39-88-266(147)209(342)135(52-29-38-87-221)250-197(330)139(97-164(300)301)254-198(331)143(100-269)229-113(14)276)204(337)246-129(62-73-158(288)289)187(320)233-118(47-24-33-82-216)179(312)252-137(94-114-42-19-18-20-43-114)194(327)253-138(96-163(298)299)195(328)237-121(50-27-36-85-219)181(314)258-144(101-270)199(332)239-119(48-25-34-83-217)178(311)251-136(92-104(3)4)193(326)236-116(45-22-31-80-214)175(308)235-122(51-28-37-86-220)189(322)263-168(110(11)273)207(340)249-133(66-77-162(296)297)192(325)264-169(111(12)274)206(339)248-126(58-69-152(224)279)184(317)243-128(61-72-157(286)287)186(319)234-120(49-26-35-84-218)180(313)256-142(95-153(225)280)211(344)268-90-40-54-148(268)202(335)257-141(93-105(5)6)210(343)267-89-41-55-149(267)203(336)259-145(102-271)200(333)238-117(46-23-32-81-215)177(310)244-132(65-76-161(294)295)191(324)265-170(112(13)275)208(341)262-167(107(8)17-2)205(338)247-130(63-74-159(290)291)188(321)241-125(57-68-151(223)278)183(316)242-127(60-71-156(284)285)185(318)232-115(44-21-30-79-213)176(309)240-124(56-67-150(222)277)173(306)227-108(9)171(304)226-99-154(281)230-123(59-70-155(282)283)182(315)260-146(103-272)212(345)346/h18-20,42-43,104-112,115-149,166-170H,16-17,21-41,44-103,213-221H2,1-15H3,(H2,222,277)…
InChIKey	UGPMCIBIHRSCBV-XNBOLLIBSA-N
IUPAC Name	(4S)-4-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-4-amino-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid
Smiles	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)C

Certificate of Analysis

Quality

Every batch of TB-500 – 10 mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥98%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All products undergo independent third-party laboratory testing for quality assurance.

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COA Lab Tests

Each product batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the product meets strict research-grade standards.