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CJC-1295 (No DAC) – 2 mg

2mg

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What Is CJC-1295 (No DAC)?

CJC-1295 (no DAC) is also known as Modified GRF 1-29 or Mod GRF (1-29). It is a synthetic peptide analog of the first 29 amino acids of natural growth hormone-releasing hormone. GHRH is also called GRF in research literature. This peptide includes specific amino acid substitutions. These changes improve stability and reduce enzymatic breakdown. They also increase binding to GHRH receptors in laboratory models. The design helps resist DPP-IV cleavage and oxidation. CJC-1295 (no DAC) is supplied as a high-purity lyophilized powder. Purity is typically 99 percent or higher by HPLC testing. It is commonly available in 2 mg or 5 mg research vials. Researchers use this compound to study pulsatile growth hormone secretion. It also helps analyze pituitary signaling and IGF-1 axis activity. The peptide is intended only for in vitro and in vivo laboratory research. It is not approved for human consumption or therapeutic use.

CJC-1295 (No DAC) Mechanism of Action

In preclinical studies, CJC-1295 (no DAC) behaves as a selective GHRH receptor agonist. It attaches to receptors on pituitary somatotroph cells. Gs-protein signaling pathways activate through this binding. The process increases intracellular cAMP levels. It also activates protein kinase A. These steps trigger pulsatile release of endogenous growth hormone. This peptide has a short half-life of about 30 minutes. It produces brief and controlled GH pulses. These pulses closely mimic natural hypothalamic and pituitary regulation. Unlike DAC variants, it does not cause sustained GH elevation. Cell and animal studies show increased GH pulse amplitude. They also show IGF-1 upregulation. No receptor desensitization appears with short exposure.

CJC-1295 (No DAC) Peptide Sequence

CJC-1295 no DAC is a linear peptide with 29 amino acids. It includes C-terminal amidation for added stability.

Sequence:

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

Key substitutions include:

D-Ala at position 2 to resist DPP-IV cleavage Gln at position 8 to reduce deamidation Ala at position 15 to improve bioactivity Leu at position 27 to prevent oxidation

Further details:

Molecular formula: C₁₅₂H₂₅₂N₄₄O₄₂

Molecular weight: approximately 3367–3368 Da

CAS number: 863288-34-0

During handling and testing these modifications improve stability. They also support consistent receptor interaction in experiments.

CJC-1295 (No DAC) 2 mg and 5 mg

CJC-1295 (no DAC) is available in standard research vial sizes. 2 mg vials work well for small-scale experiments. These experiments include cell culture assays and early dose testing. They allow precise concentration control after reconstitution. 5 mg vials suit larger or recurrent studies. These include long-term animal models and GH pulse analysis. They also support IGF-1 kinetics research. Larger vials offer better cost efficiency for extended work. Both sizes are supplied as white lyophilized powder. Reconstitution requires sterile or bacteriostatic water. All handling should occur under sterile lab conditions.

CJC-1295 (No DAC) Research

Researchers widely use CJC-1295 (no DAC) in preclinical studies. Most work involves cell-based assays and rodent models. These studies focus on pulsatile GH secretion. Results show dose-dependent increases in GH release. Elevated IGF-1 levels also appear in test systems. Natural GH pulsatility remains intact during exposure. The peptide facilitates study of endocrine signaling and receptor interactions. It also supports research on metabolic pathways such as lipolysis and protein synthesis. Models often include muscle repair and adipose tissue metabolism. Compared to DAC versions, the no-DAC form allows better pulse timing control. This makes it useful for studying natural GH rhythms. The compound is still under investigation with no regulatory approval for human use.

How to Store and Handle It?

Store unopened vials in a cool, dark, and dry place. Long-term storage works best at minus 20 degrees Celsius. Sealed vials remain stable at 2 to 8 degrees Celsius for several months. Protect the peptide from light and moisture. Avoid temperature changes during storage. After reconstitution, refrigerate the solution at 2 to 8 degrees Celsius. Use reconstituted solutions within four to six weeks. Avoid repeated freeze and thaw cycles. To prevent contamination always use PPE and ensure sterile handling.

Disclaimer

CJC-1295 (no DAC) is an investigational research peptide intended solely for in vitro laboratory research and in vivo animal studies . It is not approved by the FDA, EMA, or any regulatory authority for human use, diagnosis, treatment, or as a supplement. It is classified as a non-approved substance (e.g., WADA S0 category) and prohibited in athletic contexts. Preclinical findings do not predict human outcomes; no claims are made regarding safety or efficacy in humans. Products may carry risks including impurities or immunogenicity. Handle only in qualified research facilities with institutional oversight. All sales are for laboratory use only; not for human or veterinary consumption.

Referenced Citations

– Teichman SL, et al. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295… Journal of Clinical Endocrinology & Metabolism. doi:10.1210/jc.2005-1536.
– Ionescu M, Frohman LA. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295… Journal of Clinical Endocrinology & Metabolism. doi:10.1210/jc.2006-1702.
– Alba M, et al. (2006). Once-daily administration of CJC-1295… normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism. doi:10.1152/ajpendo.00201.2006.
– Peptide Sciences & Particle Peptides product data: Sequence, substitutions, and receptor activation details (Mod GRF 1-29).

Research Use Only

This product is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Certificate of Analysis

Quality

Every batch of CJC-1295 (No DAC) – 2 mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥98%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All products undergo independent third-party laboratory testing for quality assurance.

Request COA

Certificate of Analysis documents are available for all products. Contact us with your order number to request batch-specific documentation.

COA Lab Tests

Each product batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the product meets strict research-grade standards.