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Epithalon (Epitalon) 5mg

10mg

Epithalon 10 mg is a synthetic peptide designed exclusively for laboratory and scientific research.

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Epithalon 10 mg is a synthetic peptide designed exclusively for laboratory and scientific research. It is based on a naturally occurring peptide from the pineal gland, a neuroendocrine organ involved in circadian rhythm and hormone regulation. The compound consists of four amino acids: alanine, glutamic acid, aspartic acid, and glycine, arranged in a specific sequence. The peptide was synthesized from studies on pineal extracts to enable controlled experimental research. The 10 mg vial provides a precise and standardized dose suitable for in vitro and preclinical studies. Research focuses on telomerase pathways, particularly the peptide’s role in maintaining telomere length and chromosomal stability during cell division. Other investigations examine cellular signaling, circadian regulation, and intracellular physiology. Epithalon is supplied as a lyophilized powder to preserve stability. It must be reconstituted with sterile laboratory-grade solutions according to established protocols. This product is strictly for laboratory research and is not intended for human consumption, diagnostic use, or therapeutic applications.

Molecular Structure and Origin

Epithalon is a synthetic tetrapeptide developed in Russia at the St. Petersburg Institute of Bioregulation and Gerontology under Professor Vladimir Khavinson. The minimal active sequence was isolated from pineal tissue to create a stable and effective research compound. The chemical name is L-alanyl-L-glutamyl-L-aspartyl-glycine, with a molecular formula of C₁₄H₂₂N₄O₉ and a molecular weight of approximately 390.35 g/mol. Its compact structure ensures high purity and stability in the lyophilized 10 mg format, making it suitable for precise laboratory studies.

Mechanism of Action

Epithalon primarily acts by stimulating telomerase activity, the enzyme that adds repetitive nucleotide sequences to chromosome ends, maintaining telomere length and genomic stability during cell division. It also influences pineal gland-related processes, enhancing melatonin synthesis, circadian regulation, and antioxidant defenses. Laboratory studies show modulation of genes involved in cell proliferation, immune response, and stress resistance. All reported effects are observed in controlled in vitro and animal experiments. The 10 mg lyophilized format allows precise dosing and reproducible outcomes in research protocols.

Areas of Scientific Investigation

Epithalon is studied in various laboratory models using cells and animals. Key areas include:

Aging research: Slows functional decline and modulates lifespan-related biomarkers.
Oncology: Evaluates tumor growth and metastasis in preclinical cancer models.
Immunology: Assesses thymic activity, lymphocyte function, and cytokine signaling in aging models.
Endocrinology: Investigates hormonal regulation and reproductive function in preclinical studies.
Other studies: Includes retinal degeneration, neuroprotection, and oxidative stress indicators.

The 10 mg lyophilized format enables precise dosing and uniform application across research protocols.

Cellular Aging and Telomere Research

Telomere shortening at chromosome ends contributes to cellular aging. When telomeres reach a critical length, cells enter a state of senescence, losing their replicative capacity and accumulating damage. Laboratory studies show that Epithalon stimulates telomerase, promoting measurable telomere extension in cell cultures and increasing replicative potential. Preclinical animal studies demonstrate slowed biological aging, preserved tissue function, and improved cellular markers. The 10 mg lyophilized format allows accurate preparation and consistent dosing in telomere research.

Gene Expression and Epigenetic Modulation

Epithalon affects gene activity and epigenetic regulation without altering DNA sequences. Studies show it supports balanced expression of genes involved in cellular repair, stress response, and immune signaling. In aging models, it restores youthful gene expression patterns, increasing protective factors and reducing genes associated with inflammation or degeneration. Epigenetic effects include modulation of chromatin structure and DNA methylation, promoting access to beneficial genes while repressing harmful ones. The 10 mg lyophilized format enables consistent study of these molecular mechanisms.

Oxidative Stress and Cellular Stability

Oxidative stress occurs when reactive oxygen species exceed cellular defenses, damaging proteins, lipids, and DNA. Laboratory studies show that Epithalon enhances endogenous antioxidants, including superoxide dismutase, catalase, and glutathione peroxidase. Experimental results indicate reduced oxidative damage and improved mitochondrial function. The peptide supports membrane integrity, energy production, and cellular repair, enhancing resilience to metabolic and environmental stress. The 10 mg lyophilized format allows accurate dosing and reproducible studies on oxidative balance and cellular stability.

Scientific Relevance

Epithalon is extensively studied in laboratory models for gerontology and bioregulation. Research in cell cultures, rodents, and primates shows delayed aging markers, improved physiological parameters, and increased survival indicators. The peptide provides a synthetic tool to study telomere maintenance, oxidative balance, and cellular longevity. The 10 mg lyophilized format ensures consistent purity and stability, supporting reproducible research. All applications are confined to laboratory studies.

Intended Research Use

Epithalon 10 mg is intended solely for laboratory research. It is used in in vitro and in vivo studies to investigate telomerase activity, cellular aging pathways, and age-related biological processes. Typical applications include cell culture experiments assessing telomere dynamics and replicative potential, as well as animal studies monitoring physiological markers and longevity indicators. The 10 mg lyophilized format allows precise reconstitution and accurate dosing. This product is not intended for human or veterinary use, diagnostics, or therapeutic purposes. All handling should follow institutional safety and ethical protocols.

Storage and Handling

Epithalon 10 mg is supplied as a lyophilized powder in sealed vials to maintain stability and purity. Store unopened vials at -20°C or colder in a dry, dark environment. After reconstitution with sterile or bacteriostatic water, store the solution at 2°C to 8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Handle using proper laboratory precautions, including gloves and aseptic techniques, to prevent contamination. Controlled storage and handling ensure reliable experimental results.

Regulatory and Safety Disclaimer

Epithalon 10 mg is a laboratory-grade chemical intended only for use by trained personnel. It is not evaluated or approved by the FDA, EMA, or any other regulatory authority for human or animal consumption, diagnostics, or therapeutic purposes. This product is not a dietary supplement, medication, or food additive. Distribution is restricted to legitimate scientific research under institutional oversight. Users must comply with all applicable laws and regulations. Potential risks from improper use are unknown, as clinical data in humans are unavailable. Researchers must follow strict safety protocols, including protective equipment and proper waste disposal. The supplier assumes no responsibility for misuse outside approved research contexts.

Research Use Only

This product is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Chemical Properties

Property	GHRP-2
Molecular Formula	C14H22N4O9
Molecular Mass	390.35 g/mol
Monoisotopic Mass	390.13867829 Da
Polar Area	225 Å²
Complexity	607
XLogP	-5.5
Heavy Atom Count	27
Hydrogen Bond Donors	7
Hydrogen Bond Acceptors	10
Rotatable Bonds	12
PubChem CID	219042
InChIKey	HGHOBRRUMWJWCU-FXQIFTODSA-N
IUPAC Name	(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
SMILES	C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N

Certificate of Analysis

Quality

Every batch of Epithalon (Epitalon) 5mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥98%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All products undergo independent third-party laboratory testing for quality assurance.

Request COA

Certificate of Analysis documents are available for all products. Contact us with your order number to request batch-specific documentation.

COA Lab Tests

Each product batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the product meets strict research-grade standards.